Sodium Hyaluronate
Sodium salt of hyaluronic acid. Structurally more stable than the acid itself and more common in formulations. Molecular weight determines behaviour: high-MW (> 1 MDa) holds water at the surface, low-MW (< 50 kDa) penetrates deeper. Cosmetics typically use a mix of MWs. A baseline moisturising active across all segments.
Evidence by route
Topical application
AProven efficacy. Two or more independent RCTs with instrumental endpoints.
Moisturising effect is demonstrated in dozens of RCTs. When applied topically it retains water in the stratum corneum and visually plumps fine lines. Efficacy depends on molecular weight and concentration (typically 0.1-2%). Does not replace barrier lipids but combines well with them.
- Papakonstantinou E et al. Dermatoendocrinol. 2012;4(3):253-258.
- Pavicic T et al. J Drugs Dermatol. 2011;10(9):990-1000.
Tolerability and safety
Irritation potential
LowAllergen risk
LowPregnancy
SafeSkin types
Suitable for
Frequently asked questions
Is Sodium Hyaluronate safe during pregnancy?
Sodium Hyaluronate is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Sodium Hyaluronate for?
Sodium Hyaluronate suits: normal, dry, combination, oily, sensitive.