Pantothenic Acid
Water-soluble vitamin B5, biochemical precursor of coenzyme A. Cosmetics more often use the proalcohol form D-Panthenol (dexpanthenol), which converts to pantothenic acid on skin. The acid itself is used less often – it is unstable in aqueous formulas, and D-Panthenol has better penetration. In acne and post-procedure skin, pantothenate stimulates reparative processes in keratinocytes.
Evidence by route
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
Pantothenic acid and D-panthenol have shown effects on wound healing, irritation reduction, and barrier support in controlled studies. D-panthenol performs better in head-to-head comparisons – its proalcohol form penetrates the stratum corneum more efficiently. For extension labelling both names need to be recognised.
- Ebner F et al. Am J Clin Dermatol. 2002;3(6):427-433.
- Proksch E et al. J Dermatol Treat. 2017;28(8):766-773.
Tolerability and safety
Irritation potential
LowAllergen risk
LowPregnancy
SafeSkin types
Suitable for
Frequently asked questions
Is Pantothenic Acid safe during pregnancy?
Pantothenic Acid is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Pantothenic Acid for?
Pantothenic Acid suits: normal, dry, combination, oily, sensitive.