Linoleic Acid
Essential omega-6 fatty acid. Key component of type-1 ceramides (Ceramide EOS, EOH) – the foundation of skin barrier function. In acne patients, sebum linoleic acid is often low, contributing to pilosebaceous inflammation. Topical application in acne and dry skin restores the balance. Present in safflower, sunflower, and grape seed oils.
Evidence by route
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
Linoleic acid deficiency in acne sebum has been confirmed in several studies. Topical use as safflower oil or isolated linoleic acid improves barrier function and reduces comedone activity in small RCTs. The effect is modest but clinically meaningful in a subset of patients.
- Letawe C et al. Clin Exp Dermatol. 1998;23(2):56-58.
- Morganti P et al. Dermatol Ther. 2012;25(4):344-354.
Tolerability and safety
Irritation potential
LowAllergen risk
LowPregnancy
SafeSkin types
Suitable for
Frequently asked questions
Is Linoleic Acid safe during pregnancy?
Linoleic Acid is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Linoleic Acid for?
Linoleic Acid suits: normal, dry, combination, oily, sensitive.