Ergothioneine
Natural amino acid synthesised by certain fungi and bacteria. In humans it accumulates in tissues via the specific OCTN1 transporter. In skin it acts as a strong antioxidant, scavenging hydroxyl radicals and protecting mitochondria and DNA. Used in premium antioxidant serums.
Evidence by route
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Antioxidant activity is well established in vitro. Topical clinical studies are limited: in vivo on healthy volunteers and in vitro on photodamage models. Clinically meaningful effects on photoageing or pigmentation versus vitamin C or niacinamide in head-to-head RCTs have not been demonstrated.
- Halliwell B et al. FEBS Lett. 2018;592(20):3357-3366.
- Hseu YC et al. J Dermatol Sci. 2015;79(1):71-82.
Tolerability and safety
Irritation potential
LowAllergen risk
LowPregnancy
SafeSkin types
Suitable for
Frequently asked questions
Is Ergothioneine safe during pregnancy?
Ergothioneine is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Ergothioneine for?
Ergothioneine suits: normal, dry, combination, sensitive, oily.