Capryloyl Salicylic Acid
Lipophilic derivative of salicylic acid with a caprylic (C8) chain. Unlike plain salicylic acid, it penetrates deeper into sebaceous gland openings thanks to its lipid solubility. Developed by L'Oreal and actively used in the La Roche-Posay Effaclar line. Targets comedones and post-acne marks more than inflammation.
Evidence by route
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
Several RCTs confirmed effects in acne and post-acne pigmentation. Clinical significance is comparable to plain salicylic acid with better tolerability. Does not replace retinoids or benzoyl peroxide as first-line therapy for severe acne.
- Zeichner JA et al. J Drugs Dermatol. 2010;9(4):375-377.
- Uhoda I et al. Skin Pharmacol Physiol. 2003;16(4):256-262.
Tolerability and safety
Irritation potential
MediumAllergen risk
LowPregnancy
CautionSkin types
Suitable for
Use with caution
Frequently asked questions
Is Capryloyl Salicylic Acid safe during pregnancy?
Capryloyl Salicylic Acid should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.
What skin types is Capryloyl Salicylic Acid for?
Capryloyl Salicylic Acid suits: oily, combination. Use with caution in: sensitive, dry.
Can Capryloyl Salicylic Acid irritate the skin?
Capryloyl Salicylic Acid has moderate irritation potential. Sensitive skin may show a transient reaction that usually settles with adaptation.