Acetyl Octapeptide-3
Synthetic peptide, an elongated analogue of Argireline (Acetyl Hexapeptide-8). The manufacturer Lipotec claims SNARE-complex blockade at facial muscle synapses – a 'mechanism close to botulinum toxin'. Used in anti-age serums to smooth expression lines – glabellar, nasolabial, and outer eye wrinkles. Real effects are substantially weaker than botulinum therapy.
Evidence by route
Topical application
DVery weak or conflicting data.
The evidence base consists of manufacturer studies (Lipotec) showing a positive effect on expression lines over 28 days. There are no independent RCTs with head-to-head comparison to botulinum toxin or placebo control. 'Botox in a jar' is marketing – the clinical effect is substantially weaker.
- Lipotec. SNAP-8 technical documentation. 2010.
Tolerability and safety
Irritation potential
LowAllergen risk
LowPregnancy
SafeSkin types
Suitable for
Frequently asked questions
Is Acetyl Octapeptide-3 safe during pregnancy?
Acetyl Octapeptide-3 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Acetyl Octapeptide-3 for?
Acetyl Octapeptide-3 suits: normal, dry, combination, sensitive.