Calcium carbonate × Metformin

Calcium carbonate slightly reduces metformin intestinal absorption when taken together. Clinically significant hyperglycaemia has not been described.

The combination usually causes no specific symptoms. Each drug's individual side effects remain.

Take metformin with or just after meals; take calcium carbonate 2 hours after meals or in the evening. On the combination, monitor HbA1c on the usual schedule. In diabetics with osteoporosis, the combination is standard.