Minor
Ascorbic acid × Metformin
Vitamins. Antioxidants×Biguanides. Oral antihyperglycemic agents
Mechanism
No direct pharmacokinetic interaction. Vitamin C increases iron absorption, not metformin's.
Symptoms
The combination usually causes no specific symptoms. Each drug's individual side effects remain.
Management
No dose adjustment needed. In diabetics on metformin, ascorbic acid may improve plant-source iron absorption in patients with deficiency.