Moderate
Amlodipine × Bupropion
Calcium channel blockers (dihydropyridines)×Other antidepressants (NDRI)
Mechanism
Bupropion blocks CYP2D6. Amlodipine is minorly metabolised via CYP2D6 (main route is CYP3A4). The effect is weak – possible mild amlodipine level rise without clinically significant effect.
Symptoms
Minimal changes. Mild additional hypotension or ankle oedema possible in some patients.
Management
No dose adjustment is usually needed. In older patients and reduced ejection fraction, check blood pressure and pulse 2 weeks after starting bupropion.