Invasive aspergillosis
First line
First-line for invasive aspergillosis per 2024 and Spanish SEIMC 2023 (Herbrecht NEJM 2002 showed superiority over amphotericin B). Adult dose: loading 6 mg/kg IV twice daily on day 1, then maintenance 4 mg/kg IV twice daily or 200 mg orally twice daily. Duration – minimum 6-12 weeks depending on clinical response and immune status. Target trough concentration (TDM) 1-5.5 mcg/mL. Alternatives – isavuconazole, liposomal amphotericin B.