Major depressive disorder
Second line
Second-line for major depressive disorder, particularly with concurrent insomnia and anxiety. NG222 (2022) and 2024 set SSRIs and SNRIs (sertraline, escitalopram, venlafaxine) as first-line. Trazodone is used when sedation is desired, at 150–400 mg/day with titration over 2 weeks. Not preferred due to marked sedation and orthostatic hypotension risk.